This study compares two types of heart artery surgeries for women: Single Arterial Grafting (SAG) and Multiple Arterial Grafting (MAG). In the study, surgeons use blood vessel grafts to bypass blocked arteries. The main goal is to see if using more grafts (MAG) will lead to better health results and quality of life than using one graft (SAG). They will look at serious heart and brain problems, like heart attacks and strokes, in 2,000 women.

They will also check if the women's overall health and mental well-being improve with different grafting methods. The study involves 500 women for this part. Participants are randomly chosen to get either SAG or MAG.

• Length: Participants will be part of the study for a long time to track health outcomes.
• Visits: Regular follow-up visits are needed to monitor health status.
• Eligibility: Only women 18 or older having their first heart surgery can join.

This study is part of a larger project called ROMA, and it uses existing facilities and methods from that project. If you join, know that the study aims to improve surgery outcomes and quality of life for women like you.