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Safety, Tolerability and Pharmacokinetics of a Monoclonal Antibody Specific to B-and T-Lymphocyte Attenuator (BTLA) as Monotherapy and in Combination With an Anti-PD1 Monoclonal Antibody for Injection in Subjects With Advanced Malignancies

Testing safety and effects of new cancer treatment involving antibodies.

Recruiting
18 years and older
All
Phase 1

Study Overview: This research is testing a new treatment for people with certain advanced cancers. It uses two medications: TAB004 and toripalimab, both are types of monoclonal antibodies. These are special proteins that can help the immune system attack cancer cells. The study will check how safe these medicines are when used alone or together, and how they behave in the body (called pharmacokinetics).

Key Points:

  • Study Length: If you join, you might receive treatment every 21 days for up to 2 years.
  • Participation Requirements: You must be 18 or older with certain advanced cancers and meet other health criteria.
  • Visits and Evaluations: Regular visits will include tests like blood work and imaging to monitor your health and the treatment's effects.

This study may help researchers find better treatments for cancer, but it also has risks, like possible side effects from the medications. Participants will be closely monitored for any adverse reactions. If you're considering joining, discuss it with your doctor to understand the benefits and risks.

Study details
    Advanced Unresectable Solid Tumor
    Metastatic Solid Tumor

NCT04137900

TopAlliance Biosciences

13 December 2024

Step 1 Get in touch with the nearest study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer  to help accelerate the development of new treatments and to get notified about similar trials.

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FAQs

Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

How long does a clinical trial take place?

The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

Do I get compensated for taking part in clinical trials?

Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

How safe are clinical trials?

Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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