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Janus Kinase (JAK) Inhibitors to Preserve C-Peptide Production in New Onset Type 1 Diabetes (T1D)

Testing JAK Inhibitors to help preserve insulin production in new Type 1 Diabetes.

Recruiting
12-35 years
All
Phase 2

This study is testing medicines called JAK Inhibitors for people with new Type 1 Diabetes (T1D). JAK inhibitors are medicines that can help the body by stopping some actions of the immune system that are harmful. There are two medicines being tested: abrocitinib and ritlecitinib. Some people will get these medicines, and others will get a placebo, which is a pill that doesn't have any medicine in it. The study is "double-blind," meaning neither the doctors nor the participants will know who is getting the medicine or the placebo. This helps keep the results fair.

The study will last at least 12 months, with another 12 months of follow-up. Participants need to be between 12 and 35 years old and have been diagnosed with T1D within the last 100 days. They must also meet other health criteria to join.

  • Participants will receive free diabetes care and health check-ups during the study.
  • The study requires regular visits to the clinic for tests and monitoring.
  • Participants must avoid certain medications and conditions to ensure safety.
Study details
    Diabetes Mellitus
    Type 1

NCT05743244

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

3 November 2024

Step 1 Get in touch with the nearest study center
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  • You can expect the study team to contact you via email or phone in the next few days.
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A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

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Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

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Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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