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Cryocompression With or Without Cilostazol for the Prevention of Paclitaxel-induced Neuropathy in Patients With Gynecological Cancers

Studying cryocompression and cilostazol for nerve pain in gynecological cancer patients.

Recruiting
18 years and older
Female
Phase 2

This study is for women with gynecological cancers, like uterine or ovarian cancer, who are receiving a chemotherapy drug called paclitaxel. Paclitaxel can cause peripheral neuropathy, which is when you feel numbness, pain, or tingling in your hands and feet. The study tests if cryocompression therapy, which uses compression and cooling, with or without a medicine called cilostazol can help prevent this side effect. Cilostazol improves blood flow and might help reduce neuropathy symptoms. There are three groups: one gets paclitaxel with cryocompression and cilostazol, one gets paclitaxel with cryocompression only, and the last group gets standard care without these therapies. The study lasts for 6-9 cycles of treatment, with follow-ups up to a year.

  • The study requires several visits for treatment and follow-up.
  • Participants may experience common side effects of paclitaxel.
  • Participants receive compensation for their time and travel.
Study details
    Cervical Carcinoma
    Fallopian Tube Carcinoma
    Malignant Solid Neoplasm
    Malignant Uterine Neoplasm
    Ovarian Carcinoma
    Primary Peritoneal Carcinoma
    Vulvar Carcinoma

NCT06492070

Emory University

13 December 2024

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