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A Study of ELI-002 7P in Subjects With KRAS/NRAS Mutated Solid Tumors

Exploring ELI-002 7P for patients with KRAS/NRAS mutated tumors.

Recruiting
18 years and older
All
Phase 1/2

This research is testing a new treatment called ELI-002 7P for people with specific changes in their genes (KRAS/NRAS) that cause solid tumors. Solid tumors are lumps of cancer cells. The study has three parts: Phase 1A, Phase 1B, and Phase 2. In Phase 1A, the safety of ELI-002 7P is checked in a small group of people. Phase 1B looks at how well the treatment works for colorectal cancer by checking cancer markers in the blood. Phase 2 involves more people to see how well the treatment works compared to just watching the cancer without treatment. Participants get injections of ELI-002 7P, and some people might get the chance to switch to the treatment if their cancer gets worse.

  • The study has three stages and includes up to 164 participants.
  • Participants get injections and regular check-ups; some may switch treatments if cancer worsens.
  • Those joining must have specific gene changes and no brain metastases (cancer spread to the brain).
Study details
    Pancreatic Ductal Adenocarcinoma
    Colorectal Cancer
    KRAS G12D
    KRAS G12R
    KRAS G12V
    KRAS G12A
    KRAS G12C
    KRAS G12S
    KRAS G13D
    NRAS G12D
    NRAS G12R
    NRAS G12V
    NRAS G12C
    NRAS G12S

NCT05726864

Elicio Therapeutics

13 December 2024

Step 1 Get in touch with the nearest study center
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Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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