In this study, doctors are testing two ways to treat brain cancer that comes from small cell lung cancer and see which one better protects memory and thinking. One way is called stereotactic radiosurgery (SRS), which uses a high dose of radiation aimed only at the cancer. The other way is called whole brain radiation therapy (HA-WBRT), which gives a lower dose to the whole brain but avoids the hippocampus, a part of the brain important for memory. Patients receive a medication called memantine with HA-WBRT to help protect memory.
- Duration: Participation involves follow-up visits every 2-3 months for the first year and then every 6 months.
- Choices: Participants will be randomly assigned to either SRS over one or a few days or HA-WBRT plus memantine for two weeks.
- Eligibility: Participants must be 18 or older, have small cell lung cancer with up to ten brain tumors, and speak English or French Canadian.
By joining this study, you may help doctors learn which treatment is better at protecting memory and thinking abilities in patients with brain cancer from small cell lung cancer.
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