This study is looking at different treatments for a type of brain cancer called glioblastoma (GBM). GBM can be either newly diagnosed, meaning the first time it's found, or recurrent, meaning it has come back. The study uses a special method to match treatments with different types of patients and aims to find the most effective therapies. It will continually test new treatments as they become available. The main goal is to see if treatments help patients live longer.

To join, patients must be 18 or older and have a confirmed diagnosis of GBM. They must be able to perform daily activities (measured by the Karnofsky performance score). There are specific requirements for newly diagnosed and recurrent patients. If you had certain previous treatments, you might not be eligible. The study will be held in different locations worldwide and follows a single guideline to test several drugs at once.

• Patients must be 18+ and have a specific type of brain cancer.
• Different treatments will be tested, and participants will be assigned based on their condition.
• The study aims to find the best treatment for different patient types and improve survival.