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Combination Chemotherapy, Bevacizumab, and/or Atezolizumab in Treating Patients With Deficient DNA Mismatch Repair Metastatic Colorectal Cancer, the COMMIT Study

Exploring new treatments for advanced colorectal cancer in the COMMIT study.

Recruiting
18 years and older
All
Phase 3

This study looks at how well a combination of treatments works for a type of colon or rectal cancer called metastatic colorectal cancer, which has spread to other parts of the body. The treatments include chemotherapy (drugs like fluorouracil, oxaliplatin, and leucovorin calcium), bevacizumab (a drug that stops new blood vessels from growing to feed the cancer), and atezolizumab (a drug that helps your immune system attack cancer cells). The goal is to see if these treatments together work better than just atezolizumab alone. Patients will be randomly assigned to one of three groups to receive different treatments. After the treatments, patients will have check-ups every few months for up to five years to monitor their health.

  • Study Length: Treatment lasts up to 48 cycles, with follow-up for 5 years.
  • Visits Needed: Regular visits every two weeks during treatment and follow-ups every 8 to 12 weeks.
  • Risks: Possible side effects from the drugs, such as low blood counts or immune reactions.
Study details
    Metastatic Colorectal Adenocarcinoma
    Stage IV Colorectal Cancer AJCC v7

NCT02997228

National Cancer Institute (NCI)

16 March 2025

Step 1 Get in touch with the nearest study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer  to help accelerate the development of new treatments and to get notified about similar trials.

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A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

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Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

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The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

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Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

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Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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