Study Goal: This research is to see if the medicine baricitinib is safe compared to TNF inhibitors in people with rheumatoid arthritis (RA), focusing on blood clots called venous thromboembolic events (VTEs).
Who Can Join: Adults age 50 and older who are overweight or have had a blood clot before can join. They should have tried at least one other RA medicine that didn't work well for them.
Who Cannot Join: People who have used a JAK inhibitor before, those with more than one blood clot, cancer, or serious infections cannot join. Pregnant or breastfeeding women, and people who recently used certain vaccines or joined other trials, are also excluded.
- The study will involve regular visits for check-ups.
- Participants will receive the study medication.
- There are risks, such as possible blood clots.
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