This research study tests a new medicine called **HMPL-306** for people with blood cancers. These cancers have a special change in their genes called **IDH mutation**. The study aims to check if the medicine is safe and how well it works. It is divided into two parts: Part 1, which finds the best dose, and Part 2, which gives this dose to more patients. People involved will take the medicine by mouth.

To join, you must be 18 or older, have tried other treatments that didn't work, and have a specific IDH gene change. You can't join if you are pregnant, have certain infections or heart problems, or are on some other medications.

• **Study Length**: You will be part of the study until a doctor decides otherwise or you choose to stop.
• **Visits Needed**: Regular check-ups are required to monitor health and medicine effects.
• **Risks**: Possible side effects include reactions to the drug or health problems related to your cancer.