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Study of Targeted Therapies for the Treatment of Adult Participants With Moderate to Severe Crohn's Disease

Exploring new treatments for adults with moderate to severe Crohn's Disease.

Recruiting
18-75 years
All
Phase 2

Crohn's disease is a long-term illness that causes swelling in the digestive tract, often in the bowels. It can lead to symptoms like belly pain, diarrhea, tiredness, and weight loss. Not all treatments work for everyone, and they might stop working over time. This study tests new targeted therapies (TaTs) for adults with moderate to severe Crohn's disease. The medications being tested are risankizumab, ABBV-382, and lutikizumab. These are given as shots under the skin or through a drip into the vein.

When you join, you will be randomly assigned to a treatment group. The study has three parts: a 12-week starting period, a 12-week maintenance period, and an optional long-term part. About 500 adults will join the study at 300 sites worldwide. You will visit the hospital or clinic regularly for check-ups, blood tests, and other assessments.

  • The study involves regular hospital visits and tests.
  • The study lasts for at least 24 weeks, with an option to continue longer.
  • There may be more treatment burden compared to usual care.
Study details
    Crohn's Disease

NCT06548542

AbbVie

16 March 2025

Step 1 Get in touch with the nearest study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer  to help accelerate the development of new treatments and to get notified about similar trials.

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Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

How long does a clinical trial take place?

The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

Do I get compensated for taking part in clinical trials?

Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

How safe are clinical trials?

Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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