Sotatercept Study for Heart and Lung Problems: This study is testing a medicine called **sotatercept** to see if it helps people with **Cpc-PH** (a type of high blood pressure in the lungs) due to **HFpEF** (a condition where the heart doesn't relax well). The study will compare **sotatercept** to a placebo, which is a treatment with no active medicine, to see if it improves lung blood flow and walking ability.

Participants will be randomly placed into three groups: a placebo group, or two groups receiving different doses of **sotatercept**. The study lasts up to 114 weeks and includes several periods: screening, treatment, extension, and follow-up.

• Study duration is approximately 114 weeks with multiple visits.
• Participants must stop certain medications and use contraception if needed.
• Risks include potential side effects from the medication.

To join, you must be 18 to 85 years old, have specific heart and lung conditions, and meet other health criteria. The study has strict guidelines about medications and health conditions. This study helps researchers understand if **sotatercept** is safe and effective for this condition.