This study is for people with advanced non-small cell lung cancer (NSCLC) that is PD-L1 negative. NSCLC is a type of lung cancer, and PD-L1 is a protein that can affect how the cancer grows. This study tests if adding radiation therapy to immunotherapy (treatments that help your immune system fight cancer) can stop the cancer from growing. Radiation therapy uses high-energy x-rays to kill cancer cells, while immunotherapy uses special drugs to help your body fight the cancer.

In this study, patients will receive either just immunotherapy or a combination of immunotherapy and radiation therapy. The study will check if patients live longer and if the cancer stops growing. There will also be tests like MRIs and blood tests to see how the treatment is working.

• Time Commitment: The study lasts up to 24 months, with follow-ups for 5 years.
• Visits Needed: Regular doctor visits every 6 weeks during the study.
• Risks: Possible side effects from treatment, like tiredness or skin changes.