This study is testing a drug called Ampreloxetine to help people with a condition called symptomatic nOH (neurogenic orthostatic hypotension) who also have Multiple System Atrophy (MSA). MSA is a disease that affects the nervous system and can cause problems with movement and balance. The study lasts 20 weeks and has different parts, like screening and long-term treatment.

To join the study, you must be at least 30 years old, have a certain type of MSA, and show signs of nOH, which is when blood pressure drops too fast when standing. You can't join if you have certain other health problems, like diabetes that isn't well controlled, or if you're taking certain medications.

• Duration: The study takes 20 weeks.
• Visits: Multiple visits are required for screening and monitoring.
• Eligibility: You must be 30+ years old with specific health criteria; certain illnesses or medication use may exclude participation.

If you decide to join, you'll need to follow the rules, like not taking certain medications, and women must not be pregnant. You must also agree to use effective birth control if needed and give your consent to participate.