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A Study of Orforglipron (LY3502970) Compared With Dapagliflozin in Adult Participants With Type 2 Diabetes and Inadequate Glycemic Control With Metformin

Comparing Orforglipron and Dapagliflozin for Type 2 Diabetes Control.

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18 years and older
All
Phase 3
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  • Technical description (Original)
Study of Orforglipron vs. Dapagliflozin for Type 2 Diabetes

Study Purpose: This study is testing two drugs, orforglipron and dapagliflozin, to see which helps adults with Type 2 Diabetes (T2D) control their blood sugar better. All participants will already be taking metformin, a common diabetes medicine. The study will last about 46 weeks, which is a little less than a year.

Who Can Join: Adults with T2D who have been taking a stable dose of metformin and have a certain blood sugar level (HbA1c between 7.0% and 10.5%). Participants must have a Body Mass Index (BMI) of at least 23 kg/m², which is a measure of body fat based on height and weight.

Who Cannot Join: People with Type 1 Diabetes, those receiving treatment for eye issues related to diabetes, people with kidney issues (a low eGFR), or those with liver or pancreas problems cannot participate.

  • Study lasts approximately 46 weeks.
  • Participants must continue taking metformin.
  • Certain health conditions may disqualify you from the study.
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Study details
    Type 2 Diabetes

NCT06192108

Eli Lilly and Company

5 January 2025

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