**Study Summary:** The study looks at real-world use of devices to help treat acute ischemic stroke. This type of stroke happens when a blood clot blocks blood flow to the brain. Doctors will use a special device called the SOFIA® Flow Plus 6F Aspiration Catheter to remove the clot. The study has two groups (called cohorts), and it will check how well the devices work and if they are safe. 1. **Cohort I** focuses on checking if the treatment helps restore blood flow (revascularization) successfully. Doctors will check images and how well patients recover after 90 days. This group will involve patients aged 21 to 85, who will be treated within 8 hours of stroke symptoms. 2. **Cohort II** involves patients treated within 24 hours of symptoms, using an approved device. It will look at similar outcomes, like successful revascularization and patient recovery. **Key Points:** - Participation may require multiple follow-up visits. - **Cohort I** targets treatment within 8 hours, while **Cohort II** allows up to 24 hours. - Written consent is necessary for both groups, and those with serious health conditions or enrolled in other studies may not qualify. **Eligibility:** Patients must meet specific health criteria and provide consent for participation.