This study is for patients with a specific type of colon cancer called BRAF-mutated colon cancer. After standard surgery and chemotherapy, participants will be given either special medicine (encorafenib and cetuximab) or just be observed (usual care). Encorafenib helps stop cancer cells from growing by blocking enzymes they need. Cetuximab is a type of medicine that attaches to a protein on cancer cells to help stop their growth.

The study aims to see if giving these medicines after surgery and chemotherapy can reduce the chances of the cancer coming back. Patients will either take the medicines or just be observed. The study will also check for any side effects and how well patients survive with the different treatments.

• The study involves taking medicine or just being observed.
• Participants will need to give blood samples and have imaging tests like CT or MRI.
• Participants must have certain health conditions and have received specific chemotherapy before joining.

This study helps doctors understand if using these medicines can better prevent cancer from returning compared to usual care.