This study looks at two types of surgeries to see which works better for lowering the risk of ovarian cancer in women with a special gene change called a BRCA1 mutation. This gene change can make them more likely to get certain cancers. The two surgeries are called bilateral salpingectomy (removing the fallopian tubes) and bilateral salpingo-oophorectomy (removing both the fallopian tubes and ovaries). The study wants to find out if removing just the fallopian tubes might be almost as good as removing both the tubes and ovaries for women with this gene change.

• You need to be between 35-50 years old to join.
• The study will follow you for up to 20 years with regular check-ups.
• After the study, you cannot get pregnant naturally.

If you join, you will have one of the surgeries and regular check-ups, including ultrasounds and blood tests. They will check for symptoms and how you feel about the surgery. This study helps doctors learn how to best prevent ovarian cancer in women like you.