Study Overview: This research is testing a drug called lepodisiran to see if it can lower the risk of heart problems in adults with high lipoprotein(a), a type of fat in the blood. If you have high lipoprotein(a) and are at risk of heart disease or stroke, you might be eligible to join. The drug is given under the skin with a needle.

Eligibility:

• Participants must have lipoprotein(a) levels of 175 nmol/L or higher.
• You should be 18 or older with a history of heart disease, or 55 or older and at risk for heart problems.

Key Points:

• The study drug lepodisiran is given as an injection under the skin.
• You should not have had major heart surgery or events within 90 days before joining.
• People with severe kidney issues or uncontrolled blood pressure cannot join.

If you qualify, this study may help reduce your heart disease risk. However, participation involves regular visits and injections, and you should consider the time and any potential risks involved. Always discuss with your doctor before joining a study.