This study looks at how safe and effective a drug called *lorundrostat* is for people with *hypertension* (high blood pressure). Lorundrostat works by blocking a chemical called aldosterone that can raise blood pressure. The study will last up to 48 weeks. People taking part will need to complete a 2-week follow-up after the main study. To join, you must have been part of a previous related study and be at least 18 years old.

Participants will agree to use birth control if they can have children. If you join, you'll be required to attend all study visits and follow the study rules. Pregnant or breastfeeding women cannot join. If you start taking any medications not allowed by the study, you may not be able to continue. There will be a special part of the study called the Randomized Treatment Withdrawal (RTW) substudy for some people.

• The treatment period lasts up to 48 weeks, with a 2-week follow-up.
• You must have been in a previous related study to join.
• Pregnant or breastfeeding women cannot participate.