When a child gets a stem cell transplant, sometimes the new cells attack the body, causing a problem called graft-versus-host disease (GVHD). Doctors usually treat GVHD with a medicine called steroids, like prednisone. But steroids can have side effects like muscle weakness and problems sleeping. This study is looking at a way to use less steroids for kids with low-risk GVHD. The doctors have a special blood test called GVHD biomarkers to see if the treatment is working. They will check these tests and GVHD signs to lower steroid doses quickly if things go well.
Key Points:- The study lasts for about four weeks with weekly checkups.
- Patients will have their steroid doses lowered if they respond well, reducing side effects.
- Doctors will monitor symptoms and use surveys to understand patient quality of life.
Children age 0-21 with newly diagnosed low-risk GVHD can join if they haven't had certain GVHD treatments before. Pregnant children or those with severe infections can't participate. This study helps find safer treatments for kids with GVHD.