Phase 3 Study of Plozasiran: This study tests how safe and effective a new medicine, called plozasiran, is for adults with hypertriglyceridemia (high levels of fats called triglycerides in the blood). Participants are randomly chosen to receive either plozasiran or a placebo (a harmless pill that doesn’t have the medicine) every three months, for a total of four doses. To join, you must have a certain level of triglycerides and follow a low-fat diet while taking regular medicines to lower fat.

• Participants will need to attend multiple visits for screening and follow-ups.
• The study involves four doses over one year, with visits every three months.
• Risks include possible side effects, and some people may not qualify based on their health history.

Note: If you've recently used certain medicines targeting liver cells to lower fats, you may not be eligible. If you have had acute pancreatitis (a sudden inflammation of the pancreas) recently, you cannot join. Make sure to check with the study team for all the rules.