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Cortical Electrophysiology of Response Inhibition in Parkinson's Disease

Studying brain activity in Parkinson's response control.

Recruiting
45-75 years
All
Phase 4

This study looks at how deep brain stimulation (DBS) affects people with Parkinson's Disease (PD), a condition that causes problems with movement and thinking. The study focuses on the subthalamic nucleus (STN), a brain area important for stopping actions, like not crossing the street when a car is coming. The study involves checking the effects of DBS surgery on this area and how it might change the way people with PD control their actions. DBS uses electrical signals to help control symptoms in PD. The study aims to see if the location of these signals affects thinking and behavior.

  • Duration: Up to 18 months for PD patients, with two visits for healthy controls.
  • Participants: PD patients will be studied before, during, and after DBS surgery, and healthy individuals will also participate.
  • Compensation: Participation does not change current treatment; levodopa dosage and surgery decisions remain based on clinical needs.

Healthy participants should be aged 45-75, while PD participants should not have severe tremors or other conditions that might affect the study results. The research will help improve DBS therapy, aiming for better outcomes with fewer side effects.

Study details
    Parkinson Disease

NCT06234995

Emory University

16 March 2025

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