This study is for adults over 18 with Major Depressive Disorder (MDD). MDD is a condition causing long-lasting sadness and loss of interest. The study will test Psilocybin, a substance found in mushrooms, to see if it helps with depression. Participants will take one dose of Psilocybin (either 25 mg or 5 mg) or a placebo (a pill with no active ingredients).
The study involves a Double-blind Period of 6 weeks. "Double-blind" means neither participants nor researchers know who gets the real medicine or placebo. Participants will have support sessions with trained helpers before and after taking the medicine. After 6 weeks, there’s a 1-year Follow-up Period to check long-term effects.
- Participation lasts over a year with regular clinic visits and phone check-ins.
- Participants must meet specific health criteria and cannot have certain health conditions.
- Potential risks include side effects from Psilocybin; discuss with healthcare providers.
If you have stable depression and meet the requirements, you may qualify for the study. This is a chance to help understand new ways to treat depression.