Study Purpose: This research aims to understand how cancer treatments, like radiotherapy, affect sexual health in women. By doing so, we hope to find out why some women have more side effects than others. This could help us improve treatment methods and reduce sexual side effects for cancer patients.

What Participants Will Do:

• Share medical records, fill out health questionnaires, and provide blood samples. This helps us track health changes over time.
• Complete surveys about quality of life and any side effects every 6 months for two years. These surveys are necessary for the study.
• Optional: Provide microbiome samples (from vaginal and stool) and have ultrasound images taken.

Eligibility: Women 18+ with certain cancers planning to get radiotherapy. They should have been sexually active in the past year and can give consent. Some conditions may exclude participation, like recent major surgeries or certain infections.

Key Points:

• Duration: Surveys every 6 months for 2 years, with optional annual follow-ups.
• Visits: Medical records, blood, and microbiome samples collected during routine visits.
• Risks and Benefits: Minimal risk from blood draws; potential benefit in improved future treatments.