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Phase 1, First-in-human, Dose-finding and Expansion Study to Evaluate XmAb®808 in Combination With Pembrolizumab in Advanced Solid Tumors

Trial testing XmAb®808 and Pembrolizumab for advanced solid tumors.

Recruiting
18 years and older
All
Phase 1

This study tests a new drug, XmAb808, with pembrolizumab, a medicine already used for cancer. It's for people with advanced cancers like prostate, lung, or skin cancer. The study checks if the drug is safe and how it works in the body. Participants will get the medicine through a needle in their vein, called intravenous (IV) administration. The study has two parts: finding a safe dose (Part A) and testing it on more people (Part B).

To join, you must have certain types of cancer that didn't improve with other treatments. You must also have a life expectancy of more than 3 months and be able to do daily activities. You can't join if you're on other cancer treatments, had specific past treatments, or have active brain cancer.

  • The study involves multiple visits for treatment and testing.
  • There might be side effects as the drug is new.
  • Participants are not receiving any compensation.
Study details
    Head and Neck Squamous Cell Carcinoma
    Melanoma Excluding Uveal Melanoma
    Non-small Cell Lung Cancer
    Squamous or Non-squamous
    Urothelial Carcinoma
    Renal Cell Carcinoma
    Clear Cell
    Castration-resistant Prostate Cancer
    Ovarian Cancer
    Epithelial
    TNBC - Triple-Negative Breast Cancer
    Colorectal Cancer

NCT05585034

Xencor, Inc.

13 December 2024

Step 1 Get in touch with the nearest study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer  to help accelerate the development of new treatments and to get notified about similar trials.

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FAQs

Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

How long does a clinical trial take place?

The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

Do I get compensated for taking part in clinical trials?

Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

How safe are clinical trials?

Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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