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Sickle Cell Disease and CardiovAscular Risk - Red Cell Exchange Trial (SCD-CARRE)

Join our study on sickle cell disease and heart health.

Recruiting
18 years and older
All
Phase 3

Sickle Cell Disease (SCD) is a condition where red blood cells are shaped like a sickle (a tool with a curved, sharp edge). These abnormal cells can block blood flow and cause pain. This study is looking at whether a special type of blood transfusion, called exchange transfusion, can help adults with SCD who are at high risk for heart problems. This procedure removes some of a patient's blood and replaces it with donated blood. The trial is comparing this treatment to the usual care patients receive. It will last 12 months and involve 150 patients.

  • The study lasts for 12 months and involves multiple visits to healthcare facilities.
  • Exchange transfusions are already used for treating some SCD complications.
  • Participants will be 18 years or older with certain health markers indicating high risk.

Eligibility: Participants need to be 18 or older, have SCD, and meet certain health criteria. They must not have had regular exchange transfusions for at least 60 days. Certain medical conditions or past experiences with blood transfusions might exclude someone from participating.

Study details
    Sickle Cell Disease

NCT04084080

University of Pittsburgh

5 January 2025

Step 1 Get in touch with the nearest study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer  to help accelerate the development of new treatments and to get notified about similar trials.

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Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

How long does a clinical trial take place?

The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

Do I get compensated for taking part in clinical trials?

Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

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Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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