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Type 1 Diabetes, Endothelin, and Skeletal Muscle Mitochondrial Dysfunction: The Role of Sirtuin-1

Exploring Type 1 Diabetes' impact on muscle energy function.

Recruiting
18 years and older
All
Phase N/A

This study is for people with type 1 diabetes (T1D), which means they need insulin to control their blood sugar. The study tests if taking a supplement called resveratrol for 12 weeks helps improve certain body functions. One focus is on the endothelin-B receptor (ETBR), a part of the body that can malfunction with T1D. Another focus is on skeletal muscle mitochondrial function, which means how well muscles use energy. The study will use special tools like near infrared spectroscopy (NIRS) to check muscle health without causing pain. The aim is to see if resveratrol, which increases a protein called Sirtuin-1 (Sirt1), can help these functions work better.

  • Study lasts 12 weeks with resveratrol or placebo treatment.
  • Participants need a clinical diagnosis of T1D.
  • Cannot participate if you have certain other health issues, like uncontrolled diabetes or high blood pressure.

If you join, you'll help researchers learn more about improving health in T1D patients. Always talk to your doctor before joining a study.

Study details
    Type 1 Diabetes

NCT04449198

Augusta University

2 February 2025

Step 1 Get in touch with the nearest study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer  to help accelerate the development of new treatments and to get notified about similar trials.

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Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

How long does a clinical trial take place?

The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

Do I get compensated for taking part in clinical trials?

Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

How safe are clinical trials?

Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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