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A US Study to Evaluate Transarterial Radioembolization (TARE) in Combination With Durvalumab and Bevacizumab Therapy in People With Unresectable Hepatocellular Carcinoma Amenable to TARE

A US study testing new liver cancer treatments with TARE, durvalumab, and bevacizumab.

Recruiting
18-130 years
All
Phase 2

This study tests if a combination of two drugs, durvalumab and bevacizumab, is safe and effective for treating liver cancer called Hepatocellular Carcinoma (HCC) that can't be removed by surgery. The treatment uses a method called Transarterial Radioembolization (TARE), where tiny radioactive beads (Yttrium 90) are used to target the cancer. Participants must have HCC that is suitable for this treatment and cannot have it cured by surgery or liver transplant.

The study takes place in the US and plans to include about 125 participants at 20 locations. To join, participants need to meet certain health conditions, like having a good liver function and no cancer outside the liver. They must also not have serious heart disease, uncontrolled high blood pressure, or a history of certain health issues. Participants who have had more than one similar treatment or certain prior cancer treatments are excluded.

  • The study is conducted at about 20 sites in the US.
  • Participants need to meet specific health criteria.
  • Prior similar treatments might exclude participation.
Study details
    Hepatocellular Carcinoma (HCC)

NCT06040099

AstraZeneca

16 March 2025

Step 1 Get in touch with the nearest study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer  to help accelerate the development of new treatments and to get notified about similar trials.

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Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

How long does a clinical trial take place?

The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

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Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

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Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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