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Safety and Efficacy of Quizartinib in Children and Young Adults With Acute Myeloid Leukemia (AML), a Cancer of the Blood

Study on quizartinib for children and young adults with AML.

Recruiting
1-21 years
All
Phase 1/2

This study involves an experimental drug called quizartinib, which is not yet approved for regular use and is being tested for its safety and effectiveness in children and young adults with a blood cancer called Acute Myeloid Leukemia (AML). To join, participants must have a specific type of AML that hasn't responded to treatment or has come back after getting better.

The study has several phases:

  • Dose Escalation/De-escalation: This phase determines the right dose of quizartinib for different age groups.
  • Dose-Expansion: Here, participants receive the determined dose for their age group.
  • Continuation Therapy: Participants in remission may continue quizartinib for up to 12 cycles.

Key points:

  • The study involves multiple phases and may last several years with regular follow-ups.
  • Participants will receive quizartinib along with other treatments and may undergo a stem cell transplant.
  • Risks include side effects of quizartinib and other treatments, which will be monitored by a committee of experts.
Study details
    Acute Myeloid Leukemia

NCT03793478

Daiichi Sankyo

12 October 2024

Step 1 Get in touch with the nearest study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer  to help accelerate the development of new treatments and to get notified about similar trials.

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Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

How long does a clinical trial take place?

The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

Do I get compensated for taking part in clinical trials?

Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

How safe are clinical trials?

Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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