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High Dose Testosterone for ATM, CDK12 or CHEK2 Altered Prostate Cancers

Exploring testosterone treatment for specific prostate cancer gene changes.

Recruiting
18 years and older
Male
Phase 2

This medical study is exploring if high doses of testosterone can help men with a type of prostate cancer that has changes in specific genes (ATM, CDK12, or CHEK2). These genes are related to DNA repair, which is how cells fix themselves. The study is looking at whether people with these gene changes respond well to the treatment. Men with metastatic castration-resistant prostate cancer (mCRPC), which is a type of cancer that has spread and doesn't respond to hormonal therapy, may be eligible to participate. Participants will receive testosterone treatment until the cancer worsens or they can't tolerate it. Progress will be checked using scans and blood tests. Men interested in joining must be over 18, have specific gene changes, and meet other criteria. They cannot participate if they have certain other health issues, like brain or liver problems. The study involves frequent visits and checks for safety and side effects.

  • Eligible participants will receive high dose testosterone until the cancer progresses.
  • Safety and side effects will be monitored with regular check-ups and tests.
  • Participants must have specific gene changes and not have other major illnesses.
Study details
    Metastatic Prostate Cancer

NCT05011383

VA Office of Research and Development

13 December 2024

Step 1 Get in touch with the nearest study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer  to help accelerate the development of new treatments and to get notified about similar trials.

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