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A Trial of Dabrafenib, Trametinib and Hydroxychloroquine for Patients With Recurrent LGG or HGG With a BRAF Aberration

Join a study for recurrent brain tumors with specific genetic changes.

Recruiting
1-30 years
All
Phase 1/2

Study Overview: This is a research study to find out if adding a drug called hydroxychloroquine to other medicines (dabrafenib and trametinib) helps treat brain tumors better in kids and young adults. Brain tumors are growths in the brain that can be tough to treat. Some people have a special change (called a mutation) in their genes, like BRAF V600, which might affect how their tumor grows.

How the Study Works: The study is split into two parts. In the first part, researchers determine the safe dosage and side effects of the drug combination. In the second part, they check how well the drugs work together. The medicines are taken by mouth as capsules or a liquid for up to 2 years. Regular brain scans are needed to track progress.

Who Can Join: You can join if you have certain types of brain tumors with BRAF mutations and have already tried similar treatments. You must be at least 1 year old and meet health requirements like having enough healthy blood cells.

  • The study lasts up to 2 years with regular doctor visits.
  • There are potential side effects, including skin and eye problems.
  • Participants receive the study drug at no cost.
Study details
    Low Grade Glioma (LGG) of Brain With BRAF Aberration
    High Grade Glioma (HGG) of the Brain With BRAF Aberration
    Low Grade Glioma of Brain With Neurofibromatosis Type 1

NCT04201457

Pediatric Brain Tumor Consortium

2 February 2025

Step 1 Get in touch with the nearest study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer  to help accelerate the development of new treatments and to get notified about similar trials.

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FAQs

Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

How long does a clinical trial take place?

The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

Do I get compensated for taking part in clinical trials?

Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

How safe are clinical trials?

Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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