This study looks at how a treatment called Remote Ischemic Conditioning (RIC) affects blood markers in people with age-related brain changes. RIC involves temporarily stopping blood flow, like when a blood pressure cuff is used, to see if it helps the brain. Ischemic means not enough blood flow, and conditioning means making the body get used to a certain condition. Researchers want to find out if different doses of this treatment change the blood markers, which are substances in blood that can show how the body is responding to treatment. The study will include 40 people, aged 55 and older, who have certain changes in their brain seen on an MRI scan. Participants must be able to walk and do daily activities on their own. The study will not accept those who have had certain types of strokes or illnesses that could affect results.

• Study involves using a device for daily treatment.
• Participants must be 55+ and meet health criteria.
• Participants will not be accepted if they have certain health issues.