This study is about how a treatment called remote ischemic conditioning (RIC) affects certain blood markers. RIC is when we use a device to briefly stop blood flow in one arm, which may help the brain. We want to see if doing this more often changes these markers. The study is for people 55 years or older with specific brain changes seen on an MRI scan. These changes, called white matter hyperintensities, are areas in the brain that appear brighter on the scan and are related to aging. We hope to learn how much RIC helps, and how well people stick to the treatment. You must be able to walk and do daily activities without help to join.

• Study involves daily use of a device on your arm.
• No recent major strokes are allowed.
• Study is looking at 40 people.