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Study of ABX-002 for the Adjunctive Treatment of Major Depressive Disorder (AMPLIFY)

Exploring ABX-002 for helping treat major depressive disorder.

Recruiting
18-65 years
All
Phase 2

The study aims to see if adding a new medicine, ABX-002, helps adults with major depressive disorder who are not fully helped by their current antidepressant. This trial is called double-blind, meaning neither doctors nor patients know who gets the real medicine or a placebo (a fake pill). The study lasts about 91 days and has three parts:

  • Screening & Randomization: Check if you qualify and decide if you'll get ABX-002 or a placebo (35 days).
  • Treatment Period: Take the assigned pill every day (42 days).
  • Safety Follow-up: Ensure you're safe after treatment (2 weeks).

To join, you must have depression that hasn't lasted more than 12 months and have been on the same antidepressant for at least 6 weeks. You cannot join if you have certain mental health disorders like schizophrenia or bipolar disorder, or if you're pregnant. The study will closely watch your health and mood, and you'll need to visit the research center several times. Participating in this study means you'll help researchers learn more about treating depression.

Study details
    Major Depressive Disorder

NCT06633016

Autobahn Therapeutics, Inc.

23 February 2025

Step 1 Get in touch with the nearest study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer  to help accelerate the development of new treatments and to get notified about similar trials.

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Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

How long does a clinical trial take place?

The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

Do I get compensated for taking part in clinical trials?

Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

How safe are clinical trials?

Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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