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CRISPR-Edited Allogeneic Anti-CLL-1 CAR-T Cell Therapy in Patients With Relapsed/Refractory Acute Myeloid Leukemia

Exploring new CAR-T cell therapy for tough acute myeloid leukemia cases.

Recruiting
18 years and older
All
Phase 1

Study Overview: This study is testing a new treatment called CB-012 for adults with a type of blood cancer called acute myeloid leukemia (AML). AML is a cancer of the blood and bone marrow where the body makes abnormal blood cells. The treatment uses special cells called CAR-T cells, which are modified immune cells designed to attack cancer cells. The study is for patients whose AML has come back or doesn't respond to other treatments.

Eligibility: To join, you must have AML that is either relapsed or refractory, have tried 1 to 3 other treatments, and be healthy enough for stem cell transplant. You cannot join if you have certain other health conditions or have had previous CAR-T cell therapy.

Key Points to Consider:

  • The study is in Phase 1, focusing on safety and how the body reacts to the treatment.
  • Participants must agree to use effective birth control if they could have children.
  • Prior CAR-T therapy or recent stem cell transplant disqualifies participation.

Consider discussing with your doctor if this study might be right for you.

Study details
    Acute Myeloid Leukemia
    in Relapse
    Acute Myeloid Leukemia Refractory

NCT06128044

Caribou Biosciences, Inc.

13 December 2024

Step 1 Get in touch with the nearest study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer  to help accelerate the development of new treatments and to get notified about similar trials.

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Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

How long does a clinical trial take place?

The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

Do I get compensated for taking part in clinical trials?

Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

How safe are clinical trials?

Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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