This study aims to see if a medicine called ziltivekimab can help people with heart failure and inflammation. Inflammation is when your body is swollen or red because it's fighting something it thinks is bad. Heart failure is when your heart doesn't pump blood well. Some participants will receive ziltivekimab, and others will receive a placebo, which is a fake medicine that doesn't have any treatment effects. The medicine is given through monthly injections either with a pre-filled syringe or a pen-injector. The study will last up to 4 years and include about 20 clinic visits. Participants will need to use a smartphone app to track their injections and complete questionnaires.

• The study lasts up to 4 years with 20 clinic visits.
• Participants must use a smartphone app for tracking.
• Some will receive the real medicine, others a placebo.