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Phase 2 Trial of Mesenchymal Stem Cells in Systemic Lupus Erythematosus (MiSLE)

Testing stem cells for lupus treatment in clinical trial phase 2.

Recruiting
18-65 years
All
Phase 2

This study is looking at how safe and effective mesenchymal stem cells (MSCs) are for adults with systemic lupus erythematosus (SLE), a disease where the immune system attacks its own tissues, causing inflammation. MSCs are special cells from umbilical cords, which connect a baby to its mother in the womb. The study will compare patients getting MSCs plus their usual treatment to those getting a placebo (a fake treatment) plus usual treatment.

The trial is "double-blind," meaning neither the doctor nor the patient knows if the real drug or placebo is given. Participants will get one dose through an IV (intravenous) infusion, where the treatment goes directly into the vein.

To join, you must be 18-65 years old and have current SLE symptoms. You cannot join if you have active brain lupus, need dialysis, or have certain infections or health problems.

  • Study involves a single IV infusion and regular monitoring.
  • Participants will continue their standard treatment throughout.
  • The trial is randomized and double-blind to ensure fairness and accuracy.
Study details
    Systemic Lupus Erythematosus

NCT02633163

Medical University of South Carolina

9 February 2025

Step 1 Get in touch with the nearest study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer  to help accelerate the development of new treatments and to get notified about similar trials.

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Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

How long does a clinical trial take place?

The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

Do I get compensated for taking part in clinical trials?

Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

How safe are clinical trials?

Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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