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Study of IMPT-314 in R/R Aggressive B-cell NHL

Exploring IMPT-314 for tough B-cell Non-Hodgkin Lymphoma.

Recruiting
18 years and older
All
Phase 1/2

This study tests a new treatment called IMPT-314 for people with aggressive B-cell NHL (non-Hodgkin lymphoma). NHL is a type of cancer that starts in white blood cells. IMPT-314 uses special cells called CAR T-cells to fight cancer. CAR T-cells are your own cells changed in a lab to attack cancer. In this study, the treatment is given by a single infusion, or drip, into a vein after chemotherapy. The study has two parts. In Phase 1, about 90 people will help find the best dose. In Phase 2, 60 more people will join to see how well the treatment works. The active treatment lasts for about 2 years, with long-term follow-up for 15 years. Participants must be 18 or older and have tried other treatments without success. It's important to know that participants can't join if they have other serious health issues or have had certain treatments recently.

  • Study lasts for about 2 years, with long-term follow-up for 15 years.
  • Participants must have tried other treatments that didn't work.
  • Some health conditions or recent treatments may prevent joining the study.
Study details
    Relapsed Non-Hodgkin Lymphoma
    Refractory Non-Hodgkin Lymphoma

NCT05826535

Lyell Immunopharma, Inc.

16 March 2025

Step 1 Get in touch with the nearest study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer  to help accelerate the development of new treatments and to get notified about similar trials.

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Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

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The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

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Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

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Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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