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Ondansetron As a Strategy for Reducing Propofol Injection Pain in Pediatrics: a Randomized Controlled Trial

Testing if ondansetron reduces pain from propofol injections in kids.

Recruiting
2-17 years
All
Phase 2

This study is being conducted at Children's Healthcare of Atlanta at Egleston to see if giving Zofran (a drug used to treat nausea) before propofol (a drug for anesthesia) can reduce the pain children feel when propofol is given through an IV. In the study, children will be split into two groups: one will receive lidocaine (a common pain reliever) and the other Zofran. The goal is to improve pain control during surgery.

Key Points:

  • No compensation for participation; the study only lasts for the duration of the surgery.
  • Open to children aged 2-17 with a special type of IV access and who are healthy enough for surgery.
  • Children with certain medical conditions or procedures, like chronic pain syndrome or endoscopy, are not eligible.

Parents or guardians must agree and understand the study to sign the consent form. A special observer will check how much pain the child feels and monitor their vital signs during the study. All children in the study will receive Zofran at some point during surgery, helping the doctors compare its effects on pain reduction.

Study details
    Injection Site Irritation

NCT05378113

Emory University

2 March 2025

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