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Testing Docetaxel-Cetuximab or the Addition of an Immunotherapy Drug, Atezolizumab, to the Usual Chemotherapy and Radiation Therapy in High-Risk Head and Neck Cancer

Trying new treatments for high-risk head and neck cancer.

Recruiting
18 years and older
All
Phase 2/3

This study is testing different ways to treat high-risk head and neck cancer. This cancer starts in squamous cells, which are thin, flat cells. The usual treatment is radiation therapy with a chemotherapy drug called cisplatin. This study will try other treatments too: adding drugs like docetaxel, cetuximab, and atezolizumab. Cetuximab and atezolizumab are special medicines that help the body’s immune system fight cancer. The study will compare these treatments to see if they are better at stopping cancer from coming back.

  • Length and Follow-up: The treatment lasts 6 weeks, with follow-ups for several years.
  • Eligibility: You must have had surgery for head and neck cancer and meet specific health criteria.
  • Risks: Possible side effects include those common to cancer treatments, like fatigue and nausea.

Participants will be checked with scans and blood tests during the study. It’s important to understand all the details and discuss them with your doctor before deciding if you want to join the study.

Study details
    Oropharyngeal p16INK4a-Negative Squamous Cell Carcinoma
    Stage III Hypopharyngeal Squamous Cell Carcinoma AJCC v7
    Stage III Laryngeal Squamous Cell Carcinoma AJCC v6 and v7
    Stage III Oral Cavity Squamous Cell Carcinoma AJCC v6 and v7
    Stage III Oropharyngeal Squamous Cell Carcinoma AJCC v7
    Stage IV Hypopharyngeal Squamous Cell Carcinoma AJCC v7
    Stage IV Laryngeal Squamous Cell Carcinoma AJCC v7
    Stage IV Oral Cavity Squamous Cell Carcinoma AJCC v6 and v7
    Stage IV Oropharyngeal Squamous Cell Carcinoma AJCC v7

NCT01810913

National Cancer Institute (NCI)

16 March 2025

Step 1 Get in touch with the nearest study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer  to help accelerate the development of new treatments and to get notified about similar trials.

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What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

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Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

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The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

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Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

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Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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