This study is to check if a new medicine, *barzolvolimab*, helps adults with **prurigo nodularis**, a skin condition causing itchy bumps. Participants will be sorted into groups to get barzolvolimab shots every four weeks or a placebo (a dummy treatment), after an initial larger dose. The study includes a screening period, a 24-week treatment phase, and 16 weeks of follow-up.

• **Length of Study**: About 10 months in total, including screening, treatment, and follow-up.
• **Visits Needed**: Regular appointments for injections and check-ups.
• **Compensation**: Participants may receive payment for their time and expenses, but check with the study team.

To join, you must be 18 or older, have prurigo nodularis with many bumps, and have tried other treatments without success. Women and men must use effective birth control during and after the study. You cannot join if your skin condition is due to other causes, if you have certain infections, or if you are pregnant. Your doctor will check more criteria to confirm if you can participate.