The SHIELD study is testing a medicine called Fostemsavir (FTR) to see how safe it is and how well it works for kids and teens with HIV-1 who are not responding to their current treatment. HIV-1 is a virus that attacks the immune system, making it hard for the body to fight off infections. The study will also check if the medicine is easy for kids to swallow.

Key Points:

• The study is for kids aged 6 to under 18, weighing at least 20 kg, who have tried other HIV medicines but are not working well.
• Participants must attend regular study visits and take the medicine as directed. Some medical conditions or medicines may exclude participation.
• Girls who have started menstruation must test negative for pregnancy and agree to use birth control if sexually active.

This study will help understand how the medicine works in younger patients, aiming to improve treatment for those with tough-to-treat HIV-1.