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A Study of First-Line Olomorasib (LY3537982) and Pembrolizumab With or Without Chemotherapy in Patients With Advanced KRAS G12C-Mutant Non-small Cell Lung Cancer

Exploring new treatments for advanced lung cancer with specific mutations.

Recruiting
18 years and older
All
Phase 3

This study is exploring if adding a new medicine, called Olomorasib (LY3537982), along with Pembrolizumab and sometimes chemotherapy, can help treat people with a type of lung cancer called Non-Small Cell Lung Cancer (NSCLC) that has a specific KRAS G12C mutation. A mutation is a change in the DNA that can cause cancer. NSCLC is a common type of lung cancer, and KRAS G12C is a specific change in the KRAS gene that some NSCLC patients have. The study can last up to 3 years.

Key Points:

  • Participants will be randomly assigned to different groups to test the best dose and combination of the drugs.
  • To join, you must have the KRAS G12C mutation and meet other health criteria.
  • You cannot join if you have other specific gene mutations or if your cancer has spread to the brain.

If you are interested in joining, discuss with your doctor to see if it's a good fit for you. Participation may involve regular visits and medical tests to see how the treatment affects your health and cancer.

Study details
    Carcinoma
    Non-Small-Cell Lung
    Neoplasm Metastasis

NCT06119581

Eli Lilly and Company

9 March 2025

Step 1 Get in touch with the nearest study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer  to help accelerate the development of new treatments and to get notified about similar trials.

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Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

How long does a clinical trial take place?

The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

Do I get compensated for taking part in clinical trials?

Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

How safe are clinical trials?

Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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