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PRT3789 Monotherapy and in Combo w/Docetaxel in Participants w/Advanced or Metastatic Solid Tumors w/SMARCA4 Mutation

Exploring PRT3789 for advanced tumors with SMARCA4 mutation.

Recruiting
18 years and older
All
Phase 1

This study is for people with a specific kind of cancer called advanced or metastatic solid tumors, where the SMARCA4 gene has a problem, either missing or broken. Researchers want to test a new drug called PRT3789 to see if it's safe and how it works alone or with another medicine called docetaxel. They will give patients different amounts of PRT3789 to find the best dose that works without causing bad side effects. About 186 people will join this study, which will happen in several locations. The study will help decide the right amount of medicine to use in future studies.

  • Participants will need to visit the study site for regular checkups and tests.
  • The study will involve taking tumor samples and blood tests to check how the body reacts to the drug.
  • Participants may receive compensation for their time and travel expenses.
Study details
    Advanced Solid Tumor
    Metastatic Solid Tumor
    Non-small Cell Lung Cancers
    SMARCA4 Gene Mutation

NCT05639751

Prelude Therapeutics

2 March 2025

Step 1 Get in touch with the nearest study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer  to help accelerate the development of new treatments and to get notified about similar trials.

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A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

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Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

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The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

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Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

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Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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