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Testing the Addition of High Dose, Targeted Radiation to the Usual Treatment for Locally-Advanced Inoperable Non-small Cell Lung Cancer

Trying high-dose radiation with regular treatment for certain lung cancers.

Recruiting
18 years and older
All
Phase 3

This trial studies if adding SBRT (a type of precise radiation) to the usual treatment is better for patients with a specific type of lung cancer that can't be removed by surgery. The usual treatment includes IGRT (another radiation therapy that uses pictures to target the tumor), chemotherapy (drugs to kill or slow cancer), and immunotherapy (treatment that helps your immune system fight cancer). SBRT could mean fewer doses and less harm to healthy tissue.

  • The study may involve more frequent visits and treatments than usual care alone.
  • Participation requires regular check-ups, CT or PET scans.
  • Participants must be 18 years or older and meet specific health criteria.

Participants will be randomly assigned to receive either the standard treatment or the standard treatment plus SBRT. It is important to understand that there are potential risks, such as side effects from treatments. Additionally, if you've had treatment for other cancers, you may still be eligible. If you're considering this study, discuss with your doctor to ensure it's right for you.

Study details
    Locally Advanced Lung Non-Small Cell Carcinoma
    Stage IIB Lung Cancer AJCC v8
    Stage III Lung Cancer AJCC v8

NCT05624996

NRG Oncology

16 March 2025

Step 1 Get in touch with the nearest study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer  to help accelerate the development of new treatments and to get notified about similar trials.

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FAQs

Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

How long does a clinical trial take place?

The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

Do I get compensated for taking part in clinical trials?

Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

How safe are clinical trials?

Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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