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Testing the Addition of a Type of Drug Called Immunotherapy to the Usual Chemotherapy Treatment for Non-Small Cell Lung Cancer, ALCHEMIST Trial

Trying immunotherapy with chemotherapy for non-small cell lung cancer.

Recruiting
18 years and older
All
Phase 3

This study is looking at adding a new medicine called immunotherapy to regular chemotherapy for treating a type of lung cancer called non-small cell lung cancer that has been removed by surgery. Immunotherapy uses special proteins called monoclonal antibodies to help the immune system fight cancer. Chemotherapy uses medicines to stop cancer cells from growing. The study aims to see if adding immunotherapy can help people live longer without their disease coming back.

  • The study lasts several years with follow-up visits every few months.
  • Participants receive different treatments based on random selection.
  • Regular check-ups, including scans and blood tests, are required.

If you decide to participate, you might get a mix of medicines, including one called pembrolizumab, which is given through a vein. You will also need to be okay with regular health checks. Before joining, doctors will make sure you meet certain health conditions, like having recovered from surgery and not having other serious illnesses. This study is for people aged 18 and older and is safe for those with managed HIV. Pregnant women cannot join because the treatment might affect the baby.

Study details
    Lung Non-Small Cell Carcinoma
    Lung Non-Small Cell Squamous Carcinoma
    Lung Non-Squamous Non-Small Cell Carcinoma
    Stage II Lung Cancer AJCC v8
    Stage IIIA Lung Cancer AJCC v8
    Stage IIIB Lung Cancer AJCC v8

NCT04267848

National Cancer Institute (NCI)

16 March 2025

Step 1 Get in touch with the nearest study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer  to help accelerate the development of new treatments and to get notified about similar trials.

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Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

How long does a clinical trial take place?

The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

Do I get compensated for taking part in clinical trials?

Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

How safe are clinical trials?

Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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