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Pembrolizumab, Capecitabine, and Radiation Therapy in Treating Patients With Mismatch-Repair Deficient and Epstein-Barr Virus Positive Gastric Cancer

Testing pembrolizumab, capecitabine, and radiation for certain gastric cancer types.

Recruiting
18 years and older
All
Phase 2

This study is testing how well a medicine called pembrolizumab works when used with other treatments to fight a specific type of stomach cancer. Pembrolizumab is a special kind of medicine known as a monoclonal antibody, which helps the body attack cancer cells. Another medicine, capecitabine, is used to stop cancer cells from growing. Doctors also use radiation therapy, which involves high-energy rays, to kill cancer cells.

Key Points:

  • The study includes multiple treatment courses and surgery, lasting several months.
  • Participants will have regular follow-ups for up to four years after treatment.
  • There may be risks of side effects, but the study aims to improve survival rates and understand safety.

To join, patients must have a specific type of stomach cancer and meet other health criteria. They cannot join if they've had certain previous treatments or health conditions. Men and women must use contraception to prevent pregnancy during the study. The study will check for the cancer's response to the treatments and any side effects experienced by the participants. It's important to understand both the potential benefits and risks before deciding to join the study.

Study details
    Epstein-Barr Virus Positive
    Gastric Adenocarcinoma
    Mismatch Repair Protein Deficiency
    Stage IB Gastric Cancer AJCC v7
    Stage II Gastric Cancer AJCC v7
    Stage IIA Gastric Cancer AJCC v7
    Stage IIB Gastric Cancer AJCC v7
    Stage III Gastric Cancer AJCC v7
    Stage IIIA Gastric Cancer AJCC v7
    Stage IIIB Gastric Cancer AJCC v7
    Stage IIIC Gastric Cancer AJCC v7

NCT03257163

Rutgers, The State University of New Jersey

13 December 2024

Step 1 Get in touch with the nearest study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer  to help accelerate the development of new treatments and to get notified about similar trials.

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Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

How long does a clinical trial take place?

The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

Do I get compensated for taking part in clinical trials?

Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

How safe are clinical trials?

Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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