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Study of Plozasiran (ARO-APOC3) in Adults With Severe Hypertriglyceridemia

Research on Plozasiran for adults with high triglycerides.

Recruiting
18 years and older
All
Phase 3
Study of Plozasiran in Adults with Severe Hypertriglyceridemia

Study Overview: This research is testing a new injection called plozasiran (ARO-APOC3) to see if it helps adults with severe hypertriglyceridemia (SHTG). SHTG means having very high levels of triglycerides, which are a type of fat in your blood. The study will check how safe and effective plozasiran is. Participants will get four injections, one every three months, and their health will be checked along the way. After one year, participants can choose to continue in another part of the study.

Eligibility: To join, you need to have high triglyceride levels (≥ 500 mg/dL) and be willing to follow a low-fat diet. You should also be on medication for managing fats in your blood unless you can't tolerate them. You cannot join if you have used certain medications or have certain conditions like acute pancreatitis or a very high body mass index.

  • The study lasts for at least one year.
  • Participants will receive four injections and regular health checks.
  • There is an option to continue after the first year.
Study details
    Severe Hypertriglyceridemia

NCT06347003

Arrowhead Pharmaceuticals

23 February 2025

Step 1 Get in touch with the nearest study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer  to help accelerate the development of new treatments and to get notified about similar trials.

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