Severe Aplastic Anemia (SAA) is a rare disease where the body stops making enough new blood cells. Treatments include Immune Suppressive Therapy (IST) and Bone Marrow Transplant (BMT). Usually, if a patient doesn't have a family donor, IST is given first. If IST fails, an Unrelated Donor (URD) BMT is used. This study will compare IST and URD BMT as first treatments for SAA, checking how long they work and how they affect health and fertility. The study involves medicines and procedures that are standard for SAA. It will run for about 3.3-4.7 years and require up to 2 years of participation, with follow-ups till 5 years.
- Participants will be randomly assigned to IST or URD BMT.
- Standard treatments, no experimental drugs involved.
- Study lasts 3.3-4.7 years, with up to 2 years of active participation.