Childhood Cancer Predisposition Study (CCPS) is a research effort looking into kids at higher risk for cancer. A predisposition syndrome means these children have genes that might make them more likely to get cancer. This study will gather data and samples from these kids and their family members to learn more about cancer. Scientists hope these findings will help better detect, prevent, and treat cancer in kids.

The study will include 350 children and 700 relatives each year. It involves regular check-ins at least once a year to track health changes. The study also creates a biorepository, a special collection of tissue samples, to help with future research.

• Participants will have yearly follow-ups.
• Requires family members to join too.
• No treatment involved, just data collection.

Kids under 21 who have been diagnosed or suspected to have a cancer predisposition syndrome can join. Their parents and siblings might participate too. If a child has a family history of cancer but doesn't have the syndrome, they cannot join this study.